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Possible HIV Cure?

Two doctors in Houston, Texas, believe they might have discovered the Achilles heel of the HIV virus. KHOU's Lee McGuire reports.

To cure HIV, attack the reservoir

Researchers led by David Baltimore, professor of biology at California Institute of Technology (Caltech) started at the beginning of the process, looking for clues into how an HIV reservoir is formed in the first place.

There are two known ways that HIV can infect cells, and the human body: cell-free transmission, in which the virus infects immune system cells called T cells it encounters while floating free in plasma; and cell-to-cell transmission, in which the virus moves between T cells by using an infected donor cell as its vehicle.

Once an uninfected target cell is found, the donor cell can then directionally discharge its viral load upon the target. To replicate both types of transmission, the team infected target cells using both cell-free HIV and previously infected donor cells.

They used donor cells that lack a natural marker, HLA-A2, usually used in matching human organ donors to recipients. The target cells did have the marker, and this helped the scientists keep track of which cells were the donors and which were the targets. The target cells were infected either in the absence or in the presence of antiretroviral drugs.

Hiv Cure - Bookshelf


The cure for HIV and AIDS, with 68 case histories
646 pages
The cure for HIV and AIDS, with 68 case histories


Diseases and Disorders Diseases and Disorders

Bone marrow transplantation offers a potential cure. HIV/AIDS The human ... HIV treatment is directed at prevention of opportunistic infections using ...

HIV/AIDS treatment and prevention in India, modeling the costs and consequences
121 pages
HIV/AIDS treatment and prevention in India, modeling the costs and consequences

Although it focuses on India, the issues raised are of wider interest in the development of sustainable HIV/AIDS treatment and prevention strategies.

TB/HIV, a clinical manual
210 pages
TB/HIV, a clinical manual

ANTIRETROVIRAL THERAPY FORTHE TREATMENT OF HIV INFECTION 1I 11.1 INTRODUCTION Rapid progress in developing antiretroviral therapy (ART) led in 1996 to the ...

Biochemistry
781 pages
Biochemistry

Finding a Cure for HIV T cell HIV virus particles HIV virus cross section Cell membrane CD4 receptor Viral RNA Viral proteins Reverse transcriptase mRNA ...

Digg Headlines

(551 diggs) Getting Closer To an HIV Cure mileystone123 If you remember last December, the first ever human went from HIV-positive to HIV-negative. The “cure,” a stem cell transplant fortified with a particular sort of HIV resistant strain, was grueling, brutal, and risky.
(3 diggs) HIV cure might be here commonthinkers It could be a medical breakthrough. Doctors believe they may have found a cure for HIV.

Timothy Brown was diagnosed with the virus back in 1995.
(22 diggs) Getting Closer To an HIV Cure gamingmaster42 If you remember last December, the first ever human went from HIV-positive to HIV-negative. The “cure,” a stem cell transplant fortified with a particular sort of HIV resistant strain, was grueling, brutal, and risky.
(3 diggs) HIV Cure mnambiar Possible HIV Cure..
(1 diggs) Get better HIV cure hivreservoir Do you know how it should be your attitude towards HIV positive? Maybe you'll feel a little hesitant to accompany and interact with people with HIV.

Futurity.org – To cure HIV, attack the reservoir

While these reservoirs are not always well understood, researchers believe they have begun to decode how a reservoir of infection can persist in HIV-positive populations.  They propose that a type of HIV infection that uses infected cells to get close to uninfected cells and then discharge a large load of virus on them, may be the reason small populations of HIV-infected cells hang in even when antiretroviral drug treatment has been successful in suppressing most other infections.

researchers led by David Baltimore, professor of biology at California Institute of Technology (Caltech) started at the beginning of the process, looking for clues into how an HIV reservoir is formed in the first place.

There are two known ways that HIV can infect cells, and the human body: cell-free transmission, in which the virus infects immune system cells called T cells it encounters while floating free in plasma; and cell-to-cell transmission, in which the virus moves between T cells by using an infected donor cell as its vehicle.

...

Read more...

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